Gather all ingredients.
Place chicken breasts in a single layer in a 9×13-inch baking dish.
Mix together brown sugar, soy sauce, bourbon, dried minced onion, ginger, and garlic powder in a small bowl until well combined; pour over chicken. Cover the dish and marinate in the refrigerator for 8 hours to overnight.
Preheat the oven to 325 degrees F (165 degrees C).
Bake uncovered in the preheated oven, basting frequently, until chicken is well browned and juices run clear, about 1 1/2 hours. An instant-read thermometer inserted into the center should read at least 165 degrees F (74 degrees C).
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